Use In Pregnancy: Bromhexine crosses the placental barrier. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonic/foetal development, parturition or postnatal development. Clinical experience to date has shown no evidence of harmful effects on the foetus during pregnancy. Nonetheless, the usual precautions regarding the use of drugs during pregnancy should be observed. Especially during the first trimester, the use of bromhexine is not recommended.
There is no data on the use of guaifenesin in pregnant women. The effects, if any, on the developing fetus are unknown.
Use In Lactation: The risk on an infant when use of guaifenesin during breastfeeding is inconclusive. Guaifenesin is excreted in breast milk in small quantities. Bromhexine is expected to enter breast milk. Unfavourable effects on breastfed infants would not be expected. DiffCof Dual Action Chesty Cough Syrup is not recommended for use in nursing mothers.